Bioinformatics BI_E0002

title : Current bioinformatics tools in genomic biomedical research (Review)

author: ANDREAS TEUFEL, MARKUS KRUPP, ARNDT WEINMANN and PETER R. GALLE

year: 2006

place of pulbish : Department of Medicine I, Johannes Gutenberg University, Langenbeckstr. 1, D-55101 Mainz, Germany


abstract :

On the advent of a completely assembled human
genome, modern biology and molecular medicine stepped into
an era of increasingly rich sequence database information and
high-throughput genomic analysis. However, as sequence
entries in the major genomic databases currently rise exponentially,
the gap between available, deposited sequence data
and analysis by means of conventional molecular biology is
rapidly widening, making new approaches of high-throughput
genomic analysis necessary. At present, the only effective
way to keep abreast of the dramatic increase in sequence and
related information is to apply biocomputational approaches.
Thus, over recent years, the field of bioinformatics has rapidly
developed into an essential aid for genomic data analysis and
powerful bioinformatics tools have been developed, many of
them publicly available through the World Wide Web. In this
review, we summarize and describe the basic bioinformatics
tools for genomic research such as: genomic databases, genome
browsers, tools for sequence alignment, single nucleotide
polymorphism (SNP) databases, tools for ab initio gene
prediction, expression databases, and algorithms for promoter
prediction.