Bioinformatics BI_Q0003

Title : Interactions among type I and type II interferon, tumor necrosis factor, and ?-estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus
Author : Hooi-Ming Lee, Toru Mima, Hidehiko Sugino, Chieko Aoki, Yasuo Adachi, Naoko Yoshio-Hoshino, Kenichi Matsubara and Norihiro Nishimoto
Year Publish : 2009
Place of Publish:  Arthritis Research & Therapy
Abstract :

 Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by various clinical manifestations. Several cytokines interact and play pathological roles in SLE, although the etiopathology is still obscure. In the present study we investigated the network of immune response-related molecules expressed in the peripheral blood of SLE patients, and the effects of cytokine interactions on the regulation of these molecules.