Genomics GM_W0003

Title : Genetics and genomics of radiotherapy toxicity: towards prediction
Author : Catharine M West*1 and Gillian C Barnett2
Year : 2011
Place of publish : Genome Medicine
Abstract :

Radiotherapy is involved in many curative treatments
of cancer; millions of survivors live with the
consequences of treatment, and toxicity in a minority
limits the radiation doses that can be safely prescribed
to the majority. Radiogenomics is the whole genome
application of radiogenetics, which studies the
influence of genetic variation on radiation response.
Work in the area focuses on uncovering the underlying
genetic causes of individual variation in sensitivity
to radiation, which is important for effective, safe
treatment. In this review, we highlight recent advances
in radiotherapy and discuss results from four genomewide
studies of radiotoxicity.