Genomics GM_W0010

Title : Structure-based Functional Discovery of Proteins: Structural Proteomics
Author : Jin-Won Jung and Weontae Lee
Year : 2003
Place of publish : bmbreports.org
Abstract :

 The discovery of biochemical and cellular functions of unannotated
gene products begins with a database search of
proteins with structure/sequence homologues based on
known genes. Very recently, a number of frontier groups in
structural biology proposed a new paradigm to predict
biological functions of an unknown protein on the basis of
its three-dimensional structure on a genomic scale.
Structural proteomics (genomics), a research area for
structure-based functional discovery, aims to complete the
protein-folding universe of all gene products in a cell. It
would lead us to a complete understanding of a living
organism from protein structure. Two major
complementary experimental techniques, X-ray
crystallography and NMR spectroscopy, combined with
recently developed high throughput methods have played a
central role in structural proteomics research; however, an
integration of these methodologies together with
comparative modeling and electron microscopy would
speed up the goal for completing a full dictionary of
protein folding space in the near future.